| Date | Teams | Ballpark | Time |
|---|---|---|---|
| 03/01/2021 | Giants at Rangers | Surprise Stadium | 1:05pm |
| 03/02/2021 | Dodgers at Giants | Scottsdale Stadium | 7:05pm |
| 03/04/2021 | White Sox at Giants | Scottsdale Stadium | 1:05pm |
| 03/05/2021 | Giants at Padres | Peoria Sports Complex | 6:40pm |
| 03/06/2021 | Royals at Giants | Scottsdale Stadium | 1:05pm |
| 03/07/2021 | Giants at Reds | Goodyear Ballpark | 1:05pm |
| 03/08/2021 | Diamondbacks at Giants | Scottsdale Stadium | 1:05pm |
| 03/09/2021 | Giants at Brewers | American Family Fields of Phoenix | 1:10pm |
| 03/10/2021 | Cubs at Giants | Scottsdale Stadium | 1:05pm |
| 03/11/2021 | Giants at Angels | Tempe Diablo Stadium | 1:10pm |
| 03/12/2021 | Rockies at Giants | Scottsdale Stadium | 1:05pm |
| 03/13/2021 | Indians at Giants | Scottsdale Stadium | 1:05pm |
| 03/14/2021 | Giants at Diamondbacks | Salt River Fields at Talking Stick | 1:10pm |
| 03/15/2021 | Giants at Royals | Surprise Stadium | 1:05pm |
| 03/16/2021 | Rangers at Giants | Scottsdale Stadium | 7:05pm |
| 03/17/2021 | Giants at Rockies | Salt River Fields | 1:10pm |
| 03/18/2021 | Mariners at Giants | Scottsdale Stadium | 7:05pm |
| 03/19/2021 | Reds at Giants | Scottsdale Stadium | 7:05pm |
| 03/21/2021 | Giants at Dodgers | Camelback Ranch Glendale | 6:05pm |
| 03/22/2021 | Giants at White Sox | Camelback Ranch - Glendale | 1:05pm |
| 03/23/2021 | Giants at Indians | Goodyear Ballpark | 1:05pm |
| 03/24/2021 | Padres at Giants | Scottsdale Stadium | 7:05pm |
| 03/25/2021 | Brewers at Giants | Scottsdale Stadium | 7:05pm |
| 03/26/2021 | Giants at Cubs | Sloan Park | 1:05pm |
| 03/27/2021 | Giants at Mariners | Peoria Sports Complex | 6:40pm |
| 03/28/2021 | Athletics at Giants | Scottsdale Stadium | 1:05pm |
| 03/29/2021 | Giants at Athletics | Hohokam Stadium | 12:05pm |
Bold designates Giants spring training home game at Scottsdale Stadium.
All times are local.